Latest Science
Resistantstarch.com has collected a range of studies regarding the health benefits of resistant starch, which you can find below.
Scribner KB, Pawlak DB, Ludwig DS. Hepatic steatosis and increased adiposity in mice consuming rapidly vs.slowly absorbed carbohydrate. (2007) Obesity 15(9):2190-2199.
The purpose of this study was to determine whether a diet high in rapidly absorbed carbohydrate (RAC) vs. slowly absorbed carbohydrate (SAC), controlled for confounding dietary factors, causes non-alcoholic fatty liver disease (NAFLD) in mice with similar body weight…A diet high in RAC causes accumulation of fat in liver, adipose tissue, and plasma in mice. Therefore, a low glycemic index diet may help prevent or treat NAFLD in humans.
Toden S, Bird AR, Topping DL, Conlon MA. High red meat diets induce greater numbers of colonic DNA double-strand breaks than white meat in rats: attenuation by high amylose maize starch. (2007) Carcinogenesis. Advance access published Oct 4, 2007.
We examined whether dietary cooked red or white meat had differential effects on colonic DNA damage in rats and if resistant starch (RS), a dietary fiber component, provided protection…We have demonstrated that dietary red meat causes greater levels of colonic DNA SSB and DSB than white meat, consistent with the epidemiological data. Dietary RS protects against this damage and also against loss of the mucus barrier, probably through increased butyrate production.
Le Leu RK, Brown IL, Hu Y, Esterman A, Young GP. Suppression of azoxymethane-induced colon cancer development in rats by dietary resistant starch. (2007) Cancer Biology & Therapy Jul 19;6(10).
This study evaluated the hypothesis that feeding dietary resistant starch (as high amylose maize starch) would protect against azoxymethane (AOM)-colon carcinogenesis and favourably influence the colonic luminal environment…Feeding resistant starch significantly reduced the incidence (p<0.01) and multiplicity (p<0.05) of adenocarcinomas in the colon compared to the Control diet. Both doses of HAS resulted in similar protectin against colon tumourigenesis.
Zhang W, Wang H, Zhang Y, Yang Y. Effects of resistant starch on insulin resistance of type 2 mellitus patients. (2007) Chinese Journal of Preventive Medicine Mar 41(2): 101-104. (Article in Chinese)
The objective of this study was to observe the effects of resistant starch (RS) on insulin resistance (IR) in type 2 diabetes mellitus patients…As compared with the control group, Insulin Sensitive Index was higher and fasting blood glucose, post blood glucose, total cholesterol, triglyceridemic, froctosamine and body mass index were significantly lower in intervention group. Conclusion: RS should be effective in improving insulin resistance of type 2 diabetes mellitus patients.
Toden, S., Bird, A.R., Topping, D.L., Conlon, M.A., Dose-dependent reduction of dietary protein-induced colonocyte DNA damage by resistant starch in rats correlates more highly with caecal butyrate than with other short chain fatty acids (2007) Cancer Biology & Therapy 6(2): 253-8.
Previous studies have shown increased levels of colonocyte DNA damage (as measured by the comet assay) and thinning of the colonic mucus layer in rats fed higher dietary protein as casein or red meat with highly digestible starch. Feeding resistant starch (RS) as high amylose maize starch (HAMS) opposed these changes. However, the dietary level of HAMS was relatively high (48% by weight) so this study was conducted to establish whether HAMS had the same effects at lower dietary levels…These data show that HAMS prevents protein-induced colonic DNA damage in a dose-dependent manner. Inclusion of 10% HAMS was found to be sufficient to oppose colonocyte DNA damage, and to increase caecal and fecal SCFA pools.
Brown M, Higgins J, Storlien L. Consumption of resistant starch decreases postprandial lipogenesis in white adipose tissue of the rat. Nutrition Journal 2006, 5:25.
Chronic consumption of diets high in resistant starch (RS) leads to reduced fat cell size compared to diets high in digestible starch (DS) in rats and increases total and meal fat oxidation in humans. On a whole body level, this attenuation of fat deposition in WAT in response to a RS diet could be significant for the prevention of weight gain in the long-term.
Toden S, Bird AR, Topping DL, Conlon MA. Resistant starch prevents colonic DNA damage induced by high dietary cooked red meat or casein in rats. Cancer Biol Ther. 2006 Mar;5(3):267-72.
Addition of RS2 high amylose corn resistant starch (RS) to the diet abolished the increase in DNA damage and the loss of colonic mucus thickness induced by high casein and high cooked red meat diets. Because DNA damage is an early step in the initiation of cancer, these findings suggest that increased DNA damage due to high dietary protein as cooked red meat or casein could increase colorectal cancer risk but inclusion of resistant starch in the diet could significantly reduce that risk.
Zhou J, Hegsted M, McCutcheon KL, Keenan MJ, Xi X, Raggio AM, Martin RJ. Peptide YY and Proglucagon mRNA Expression Patterns and Regulation in the Gut. Obesity (Silver Spring). 2006 Apr;14(4):683-9.
Peptide YY (PYY) and proglucagon (the gene that encodes glucagon-like peptide-1) were measured in epithelial cells collected from the colon of rats fed either a normal diet or a RS2 high amylose corn resistant starch diet for 4 weeks. The gene expression patterns for PYY and proglucagon were up-regulated in the cecum and colon in resistant-starch-fed rats. Butyrate increased PYY and proglucagon gene expression in a dose-dependent manner in vitro.
Robertson, M.D., Bickerton, A.S., Dennis, A.L., Vidal, H., Frayn, K.N. Insulin-sensitizing effects of dietary resistant starch and effects on skeletal muscle and adipose tissue metabolism. American Journal of Clinical Nutrition, (2005), 82, 559-567.
Weickert, M.O., Mohlig, M., Koebnick, C., Holst, J.J., Namsolleck, P., Ristow, M., Osterhoff, M., Rochlitz, H., Rudovich, N., Spranger, J., Pfeiffer, A.F.H. Impact of cereal fibre on glucose-regulating factors. Diabetologia, (2005), 48, 2343-2353.
Behall, K.M., Scholfield, D.J. Food amylose content affects postprandial glucose and insulin responses. Cereal Chemistry, (2005), 82 6, 654-659.
Drzikova, B., Dongowski, G., Gebhardt, E. Dietary fibre-rich oat-based products affect serum lipids, microbiota, formation of short-chain fatty acids and steroids in rats. British Journal of Nutrition, (2005), 94, 1012-1025.
Le Leu, R.K., Brown, I.L., Hu, Y., Bird, A.R., Jackson, M., Esterman, A., Young, G.P. A synbiotic combination of resistant starch and Bifidobacterium lactis facilitates apoptotic deletion of carcinogen-damaged cells in rat colon. Journal of Nutrition, (2005), 135, 996-1001.
Morita, T., Kasaoka, S., Kiriyama, S., Brown, I.L., Topping, D.L. Comparative effects of acetylated and unmodified high-amylose maize starch in rats. Starch, (2005), 57, 246-253.
Morita, T., Hayashi, J., Motoi, H., Yagishita, T., Takeya, K., Sugiyama, K., Kiriyama, S. In vitro and in vivo digestibility of recrystallized amylose and its application for low glycemic foods. Journal of Food Science, (2005), 70, S179-S185.
Toden, S., Bird, A.R., Topping, D.L., Conlon, M.A. Differential effects of dietary whey and casein on colonic DNA damage in rats. The Australian Journal of Dairy Technology, (2005), 60, 44-46.
Gajda, M., Flickinger, EA., Greshop, C.M., Bauer, L.L., Merchen, N.R., Fahey, G.C. Corn hybrid affects in vitro and in vivo measures of nutrient digestibility in dogs. Journal of Animal Science, (2005), 83, 160-171.
Choi, Y.M., Oh, S.H., Yu, K.W., Shin, K.S., Ra, K.S., Park, C.S., Kim, K.M., Suh, H.J. Characteristics of resistant starch: a Hi-maize diet that is fortified with the functions of dietary fiber. Journal of the Korean Society of Food Science and Nutrition, (2005), 34, 1-6.
Iyer, C., Kailasapathy, K. Effect of co-encapsulation of probiotics with prebiotics on increasing the viability of encapsulated bacteria under in vitro acidic and bile salt conditions and in yoghurt. Journal of Food Science (2005), 70, M18-M23.
Yonekura, L., Suzuki, H. Effects of dietary zinc levels, phytic acid and resistant starch on zinc bioavailability in rats European Journal of Nutrition (September, 2005) 44(6):384-91.
Drzikova, B., Dongowski, G., Gebhardt, E., Habel, A. The composition of dietary fibre-rich extrudates from oat affects bile acid binding and fermentation in vitro. Food Chemistry (2005), 90, 181-192.
Han, K.H., Iijuka, M., Shimada, K., Sekikawa, M., Kuramochi, K., Ohba, K., Ruvini, L., Chiji, H., Fukashima, M. Adzuki resistant starch lowered serum cholesterol and hepatic 3-hydrosy-3-methylglutaryl-CoA mRNA levels and increased hepatic LDL-receptor and cholesterol 7alpha-hydroxylase mRNA levels in rats fed a cholesterol diet. British Journal of Nutrition (December, 2005) 94(6):902-908.
Yang, C.Z., Shu, X.L., Zhang, L.L., Wang, X.Y., Zhao, H.J., Ma, C.X., Wu, D.X. Starch properties of mutant rice high in resistant starch J Agric Food Chem (January 25, 2006) 54(2):523-8.
Granfeldt,Y., Wu, X., Bjorck, I. Determination of glycaemic index; some methodological aspects related to the analysis of carbohydrate load and characteristics of the previous evening meal. (January, 2006) European Journal of Clinical Nutrition 60(1):104-112.
Patten, G.S., Conlon, M.A., Bird, A.R., Adams, M.J., Topping, D.L.,and Abeywardena, M.Y., Interactive Effects of Dietary Resistant Starch and Fish Oil on Short-Chain Fatty Acid Production and Agonist-Induced Contractility in Ileum of Young Rats. Digestive Diseases and Sciences (2006) 51, 254-261.
Raghupathy, P., Ramakrishna, B.S., Oommen, S.P., Ahmed, M.S., Priyaa, G., Dziura, J., Young, G.P., Binder, H.J. Amylase-resistant starch as adjunct to oral rehydration therapy in children with diarrhea Journal of Pediatric Gastroenterology and Nutrition (April, 2006) 42:362-368.
Bajka, B.H., Topping, D.L., Cobiac, L., Clarke, J.M. Butyrylated starch is less susceptible to enzymic hydrolysis and increases large-bowel butyrate more than high-amylose maize starch in the rat. British Journal of Nutrition (August, 2006) 96:276-282.
Fassler, C., Arrigoni, E., Venema, K., Brouns, F., Amado, R. In vitro fermentability of differently digested resistant starch preparations Molecular Nutrition &. Food Research (November 13, 2006) 50(12):1220-1228.
Kotzampassi, K., Giamarellos-Bourboulis, E.J., Voudouris, A., Kazamias, P., Eleftheriadis, E. Benefits of a synbiotic formula (Synbiotic 2000Forte(®)) in critically ill trauma patients: Early results of a randomized controlled trial World Journal of Surgery (October, 2006) 30(10): 1848-1855.
Martinez-Puig, D., Mourot, J., Ferchaud-Roucher, V., Anguita, M., Garcia, F., Krempf, M., Perez, J.F. Consumption of resistant starch decreases lipogenesis in adipose tissues but not in muscular tissues of growing pigs Livestock Science (2006) 99:237-247.
Hernandez-Salazar, M., Agama-Acevedo, E., Sayago-Ayerdi, S.G., Tovar, J., Bello-Perez, L.A. Chemical composition and starch digestibility of tortillas prepared with non-conventional commercial nixtamalized maize flours International Journal of Food Sciences and Nutrition (February/March 2006) 57(1/2): 143-150.
Han, X-Z, Ao, Z, Janaswamy S, Jane, J-L., Chandrasekaran, R, Hamaker, B.R. Development of a low glycemic maize starch: preparation and characterization Biomacromolecules (2006) 7:1162-1168.
Chang, M.J., Soel, S.M., Bang, M.H., Park, J.H.Y., Kang, N.E., Kim, W.K. Interactions of high amylose starch and deoxycholic acid on gut functions in rats Nutrition (2006) 22:152-159.
Han, S.H., Chung, M.J., Lee, S.J., Rhee, C. Digestion-resistant fraction from soybean [Glycine max (L.) Merrill] induces hepatic LDL receptor and CYP7A1 expression in apolipoprotein e-deficient mice. Journal of Nutritional Biochemistry (October, 2006) 17(10):682-8.
Gonzalez-Soto, R.A., Sanchez-Hernandez, L., Solorza-Feria, J., Nunez-Santiago, C., Flores-Huicochea, E., Bello-Perez, L.A. Resistant starch production from non-conventional starch sources by extrusion (2006) Food Sci Tech Intl (2006) 12(1): 5-11.
Nugent, A.P. Health properties of resistant starch. Nutrition Bulletin, (2005), 30 1, 27-54.
Brown, I., Yotsuzuka, M., Birkett, A., Henriksson, A. Prebiotics, synbiotics and resistant starch. Journal of the Japanese Association of Dietary Fiber Research (2006) 10(1).
Sajilata, M.G., Singhal, R.S., Kulkarni, P.R., Resistant Starch – A Review. Comprehensive Reviews in Food Science and Food Safety (2006) 5:000-000.
M. Keenan, et. al. Effects of Resistant Starch, A Non-digestible Fermentable Fiber, on Reducing Body Fat. OBESITY. 2006 September; 14( 9): 1523-1534.
American Diabetic Association. Nutrition Recommendations and Interventions for Diabetes–2006. Diabetes Care. 2006 September;29(9): 2140-2157.
Xiong Liu, Taro Kishida, Kiyoshi Ebihara. High Amylose Cornstarch Decreases Plasma Triacylglycerol Concentration, but not Plasma Cholesterol, in a Dose-Dependent Manner. Journal of Food Science. 2006 June/July;71(5):379.
Hanan Gancz, Orly Niderman-Meyer, Meir Broza, Yechezkel Kashi, and Eyal Shimoni. Adhesion of Vibrio cholerae to Granular Starches. Applied and Environmental Microbiology 2005 Aug;71(8):4850-4855.
Jacobasch G, Dongowski G, Schmiedl D, Muller-Schmehl K. Hydrothermal treatment of Novelose 330 results in high yield of resistant starch type 3 with beneficial prebiotic properties and decreased secondary bile acid formation in rats. Br J Nutr. 2006 Jun;95(6):1063-74.
Behall KM, Scholfield DJ, Hallfrisch JG, Liljeberg-Elmstahl HG. Consumption of both resistant starch and beta-glucan improves postprandial plasma glucose and insulin in women. Diabetes Care. 2006 May;29(5):976-81.
Brighenti F, Benini L, Del Rio D, Casiraghi C, Pellegrini N, Scazzina F, Jenkins DJ, Vantini I. Colonic fermentation of indigestible carbohydrates contributes to the second-meal effect. Am J Clin Nutr. 2006 Apr;83(4):817-22.
Regina A, Bird A, Topping D, Bowden S, Freeman J, Barsby T, Kosar-Hashemi B, Li Z, Rahman S, Morell M. High-amylose wheat generated by RNA interference improves indices of large-bowel health in rats. Proc Natl Acad Sci U S A. 2006 Mar 7;103(10):3546-51.
Subramanya, S., Ramakrishna, B.S., Binder.H.J., Farthing, M.J., Young, G.P., Evaluation of oral rehydration solution by whole-gut perfusion in rats: effect of osmolarity, sodium concentration and resistant starch. Journal of Pediatric Gastroenterology and Nutrition (November, 2006) 42(5):568-575.
Fassler, C., Arrigoni, E., Venema, K., Hafner, V., Brouns, F., Amado, R. Digestibility of resistant starch containing preparations using two in vitro models European Journal of Nutrition (2006) Published online Oct 11, 2006.
Scheiwiller, J., Arrigoni, E., Brouns, F., Amado, R. Human faecal microbiota develops the ability to degrade type 3 resistant starch during weaning. Journal of Pediatric Gastroenterology and Nutrition (November, 2006) 43(5): 584-591.
Juarez-Garcia, E., Agama-Acevedo, E., Sarago-Ayerdi, S.G., Rodriguez-Ambriz, S.L., Bello-Perez, L.A., Composition, digestibility and application in breadmaking of banana flour. Plant Foods in Human Nutrition (September, 2006) 61(3):131-7.
Bauer-Marinovic, M., Florian, S., Muller-Schmehl, K., Glatt, H., Jacobasch, G. Dietary resistant starch type 3 prevents tumor induction by 1,2-dimethylhydrazine and alters proliferation, apoptosis and dedifferentiation in rat colon Carcinogenesis (September 2006) 27(9): 1849-1859.